Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition EPIC-Potsdam studyReport as inadecuate




Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition EPIC-Potsdam study - Download this document for free, or read online. Document in PDF available to download.

Diabetologia

, Volume 55, Issue 10, pp 2613–2621

First Online: 01 July 2012Received: 23 February 2012Accepted: 06 June 2012

Abstract

Aims-hypothesisThe aim of this study was to prospectively examine the association between body iron stores and risk of type 2 diabetes.

MethodsWe designed a case–cohort study among 27,548 individuals within the population-based European Prospective Investigation into Cancer and Nutrition EPIC-Potsdam study. During 7 years of follow-up, 849 incident cases of type 2 diabetes were identified. Of these, 607 remained for analyses after exclusion of participants with missing data or abnormal glucose levels at baseline. A sub-cohort of 2,500 individuals was randomly selected from the full cohort, comprising 1,969 individuals after applying the same exclusion criteria.

ResultsAfter adjustment for age, sex, BMI, waist circumference, sports activity, bicycling, education, occupational activity, smoking habit, alcohol consumption and circulating levels of γ-glutamyltransferase, alanine aminotransferase, fetuin-A, high-sensitivity C-reactive protein, adiponectin, HDL-cholesterol and triacylglycerol, higher serum ferritin concentrations were associated with a higher risk of type 2 diabetes RR in the highest vs lowest quintile, 1.73; 95% CI 1.15, 2.61; ptrend = 0.002. No significant association was observed for soluble transferrin receptor RR 1.33; 95% CI 0.85, 2.09; ptrend = 0.50. The soluble transferrin receptor-to-ferritin ratio was significantly inversely related to risk RR 0.61; 95% CI 0.41, 0.91; ptrend = 0.02.

Conclusions-interpretationHigh ferritin levels are associated with higher risk of type 2 diabetes independently of established diabetes risk factors and a range of diabetes biomarkers whereas soluble transferrin receptor concentrations are not related to risk. These results support the hypothesis that higher iron stores below the level of haemochromatosis are associated with risk of type 2 diabetes.

KeywordsBody iron store Ferritin Soluble transferrin receptor Type 2 diabetes AbbreviationsALTAlanine aminotransferase

EPICEuropean Prospective Investigation into Cancer and Nutrition

GGTγ-Glutamyltransferase

hs-CRPHigh-sensitivity C-reactive protein

sTfRSoluble transferrin receptor

TfRTransferrin receptor

An erratum to this article can be found at http:-dx.doi.org-10.1007-s00125-012-2704-0.

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Author: J. Montonen - H. Boeing - A. Steffen - R. Lehmann - A. Fritsche - H.-G. Joost - M. B. Schulze - T. Pischon

Source: https://link.springer.com/







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