Controlling the cortical actin motorReport as inadecuate

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, Volume 249, Issue 4, pp 1001–1015

First Online: 15 April 2012Received: 06 March 2012Accepted: 21 March 2012


Actin is the essential force-generating component of the microfilament system, which powers numerous motile processes in eukaryotic cells and undergoes dynamic remodeling in response to different internal and external signaling. The ability of actin to polymerize into asymmetric filaments is the inherent property behind the site-directed force-generating capacity that operates during various intracellular movements and in surface protrusions. Not surprisingly, a broad variety of signaling pathways and components are involved in controlling and coordinating the activities of the actin microfilament system in a myriad of different interactions. The characterization of these processes has stimulated cell biologists for decades and has, as a consequence, resulted in a huge body of data. The purpose here is to present a cellular perspective on recent advances in our understanding of the microfilament system with respect to actin polymerization, filament structure and specific folding requirements.

KeywordsCell motility Actin dynamics Actin-binding proteins Actin folding Molecular chaperone CCT Handling Editor: David Robinson

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Author: Julie Grantham - Ingrid Lassing - Roger Karlsson


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