Development of a lepto-igm eiacr test to diagnose leptospirosis disease in costa rican patient samples. Report as inadecuate




Development of a lepto-igm eiacr test to diagnose leptospirosis disease in costa rican patient samples. - Download this document for free, or read online. Document in PDF available to download.

Bernal León ; Lizeth Taylor ; Kirsten Visona ;Investigación Clínica 2007, 48 3

Author: María de los A. Valverde J

Source: http://www.redalyc.org/articulo.oa?id=372937668004


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Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Valverde J, María de los A.; León, Bernal; Taylor, Lizeth; Visona, Kirsten Development of a Lepto-IgM EIACR test to diagnose leptospirosis disease in Costa Rican patient samples. Investigación Clínica, vol.
48, núm.
3, 2007, pp.
295-304 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937668004 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 48(3): 295 - 304, 2007 Development of a Lepto-IgM EIACR test to diagnose leptospirosis disease in Costa Rican patient samples. María de los A.
Valverde J1, Bernal León2, Lizeth Taylor2 and Kirsten Visona2. Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, INCIENSA. Tres Ríos, San José, Costa Rica and 2International Center for Medical Research and Training, Louisiana State University, USA.
E-mail: mvalverde@inciensa.sa.cr 1 Key words: Leptospira sp., anti-IgM EIA, serology diagnostic, zoonosis. Abstract.
Leptospirosis is an endemic disease throughout Costa Rica, which could be misdiagnosed because manifestations of this febrile disease may vary from mild flu-like symptoms to severe illness involving vital organs such as liver and lungs.
Therefore an early specific diagnosis is important to ensure a favorable clinical outcome.
The purpose of this study was to develop a Leptospira sp.
anti-IgM EIA (Lepto-IgM EIACR) test and to compare it using Lepto-Dipstick IgM (Lepto-DS IgM) and PanBio-EIA IgM with the Microscopy Agglutination test (MAT) as a reference assay.
Sera from 736 healthy blood donors were used as negative controls to calculate specificity (97.1%), Confidence Interval 95 (CI (96-98).
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