Effect of polyvinylpyrrolidone on sperm function and early embryonic development following intracytoplasmic sperm injection in human assisted reproductionReport as inadecuate




Effect of polyvinylpyrrolidone on sperm function and early embryonic development following intracytoplasmic sperm injection in human assisted reproduction - Download this document for free, or read online. Document in PDF available to download.

Reproductive Medicine and Biology

, Volume 11, Issue 4, pp 165–176

First Online: 10 April 2012Received: 17 December 2011Accepted: 13 March 2012

Abstract

The objective here was to review the effects of polyvinylpyrrolidone PVP upon sperm function and embryonic development in humans. PVP has been used successfully in intracytoplasmic sperm injection ICSI to facilitate the handling and immobilization of sperm for both domestic animals and humans. In our previous reports, PVP solution exists locally in embryos injected during the early developmental period, and also exerts influence over the developmental capacity of such embryos. In other reports, PVP causes significant damage to sperm membranes that can be detected by transmission electron microscopy, and has been associated with chromosomal abnormalities in pregnancy derived from ICSI embryos. In some Japanese clinics, PVP-free media has been used for sperm immobilization in order to optimise safety. Consequently, it is strongly suggested that the success rate of fertilization and clinical pregnancy could be improved by using PVP-free solution for human ICSI. In conclusion, our interpretation of the available data is to perform ICSI without PVP or select a lower concentration of PVP solution in order to reduce safety for pregnancy and children born via ICSI.

KeywordsSperm capacitation Embryo development Polyvinylpyrrolidone PVP Clinical utility in vitro embryo production in human  Download fulltext PDF



Author: Yoku Kato - Yoshikazu Nagao

Source: https://link.springer.com/







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