Differential expression of hsp70 and ultrastructure of heart and liver tissues of rats treated with adriamycin: protective role of l-carnitine Report as inadecuate




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Noraidys Porras ;Investigación Clínica 2007, 48 1

Author: Mirian Strauss

Source: http://www.redalyc.org/articulo.oa?id=372937666003


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Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Strauss, Mirian; Porras, Noraidys Differential expression of HSP70 and ultrastructure of heart and liver tissues of rats treated with adriamycin: protective role of L-carnitine Investigación Clínica, vol.
48, núm.
1, 2007, pp.
33-43 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937666003 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 48(1): 33 - 43, 2007 Differential expression of HSP70 and ultrastructure of heart and liver tissues of rats treated with adriamycin: protective role of L-carnitine. Mirian Strauss and Noraidys Porras. Sección de Biología Celular, Instituto de Medicina Tropical, Universidad Central de Venezuela.
Apartado Postal 47019, Caracas 1041-A, Venezuela. E-mail: mstraussve@yahoo.com Key words: HSP70; ultrastructure; adriamycin; heart-liver; L-carnitine. Abstract.
The anticancer drug adriamycin has been associated to tissular oxidative stress.
In this regard, the promotion of anti-stress protein synthesis by L-carnitine has been suggested in rat adriamycin-induced cardiomyopathy in the long-term.
However, the citoprotective role of L-carnitine in cardiac and hepatic tissues after short-term adriamycin treatment is unknown.
HSP70 in the supernatant of the homogenized cardiac and hepatic tissues after short-term adriamycin treatment was determined by Western blot analysis with and without L-carnitine protection and compared to the subcellular characteristics of both tissues by transmission electron microscopic analysis. Female Sprague-Dawley rats (n = 6), body weight 40-60g, were randomized into four groups: control, adriamycin, L-carnitine and L-carni...





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