EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assaysReport as inadecuate




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Tumor Biology

, Volume 33, Issue 5, pp 1319–1326

First Online: 11 April 2012Received: 09 February 2012Accepted: 12 March 2012

Abstract

Tumor-associated autoantibodies AAbs have been described in patients with lung cancer, and the EarlyCDT®-Lung test that measures such AAbs is available as an aid for the early detection of lung cancer in high-risk populations. Improvements in specificity would improve its cost-effectiveness, as well as reduce anxiety associated with false positive tests. Samples from 235 patients with newly diagnosed lung cancer and matched controls were measured for the presence of AAbs to a panel of six p53, NY-ESO-1, CAGE, GBU4-5, Annexin I, and SOX2 or seven p53, NY-ESO-1, CAGE, GBU4-5, SOX2, HuD, and MAGE A4 antigens. Data were assessed in relation to cancer type and stage. The sensitivity and specificity of these two panels were also compared in two prospective consecutive series of 776 and 836 individuals at an increased risk of developing lung cancer. The six-AAb panel gave a sensitivity of 39 % with a specificity of 89 %, while the seven-AAb panel gave a sensitivity of 41 % with a specificity of 91 % which, once adjusted for occult cancers in the population, resulted in a specificity of 93 %. Analysis of these AAb assays in the at-risk population confirmed that the seven-AAb panel resulted in a significant increase in the specificity of the test from 82 to 90 %, with no significant change in sensitivity. The change from a six- to a seven-AAb assay can improve the specificity of the test and would result in a PPV of 1 in 8 and an overall accuracy of 92 %.

KeywordsAutoantibodies Lung cancer Lung cancer diagnosis  Download fulltext PDF



Author: Caroline J. Chapman - Graham F. Healey - Andrea Murray - Peter Boyle - Chris Robertson - Laura J. Peek - Jared Allen - A

Source: https://link.springer.com/







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