EPR Studies of DOPA–Melanin Complexes with Netilmicin and CuII at Temperatures in the Range of 105–300 KReport as inadecuate




EPR Studies of DOPA–Melanin Complexes with Netilmicin and CuII at Temperatures in the Range of 105–300 K - Download this document for free, or read online. Document in PDF available to download.

Applied Magnetic Resonance

, Volume 43, Issue 3, pp 341–351

First Online: 13 May 2012Received: 16 February 2012

Abstract

The application of electron paramagnetic resonance EPR spectroscopy in pharmacy of melanin complexes with netilmicin and CuII was presented. The continuous microwave saturation of EPR spectra of DOPA–melanin and the complexes was performed. EPR spectra were measured on an X-band 9.3 GHz spectrometer at temperatures in the range of 105–300 K. Paramagnetic copper ions decrease the intensity of the EPR lines of melanin’s free radicals. It was found that fast spin–lattice relaxation characterizes DOPA–melanin–CuII complexes. Slow spin–lattice relaxation processes exist in melanin’s paramagnetic centers of DOPA–melanin and DOPA–melanin–netilmicin, DOPA–melanin–netilmicin–CuII, DOPA–melanin–CuII–netilmicin complexes. Spin–lattice relaxation processes are faster at higher temperatures. The homogeneous broadening of EPR lines for melanin complexes was observed. The practical consequences of differences between paramagnetic properties of melanin complexes with netilmicin and the complexes with CuII were discussed.

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Author: Magdalena Zdybel - Barbara Pilawa - Ewa Buszman - Dorota Wrześniok - Ryszard Krzyminiewski - Zdzisław Kruczyński

Source: https://link.springer.com/







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