Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious AgentsReport as inadecuate




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1 ICR - Institut de Chimie Radicalaire

Abstract : 5-Nitroimidazoles are drugs having both antiprotozoal and antibacterial activity, but show mutagenicity and development of resistance observed particularly with metronidazole. For the development of new potentially safer derivatives, we investigated new strategies of synthesis: such as Vicarious Nucleophilic Substitution of hydrogen VNS, palladium-catalyzed cross-coupling reactions Suzuki-Miyaura, Sonogashira… and electron transfer reactions Unimolecular Radical Nucleophilic Substitution SRN1, TDAE methodology applied in 5-nitroimidazole series.





Author: Maxime Crozet - Thierry Terme - Patrice Vanelle -

Source: https://hal.archives-ouvertes.fr/



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