Impact of transcription factor 7-like 2 TCF7L2 on pancreatic islet function and morphology in mice and menReport as inadecuate




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Diabetologia

, Volume 55, Issue 10, pp 2559–2561

First Online: 05 August 2012Received: 28 May 2012Accepted: 22 June 2012

Abstract

Common genetic variations in the gene encoding transcription factor 7-like 2 TCF7L2 reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.

KeywordsApoptosis Glucagon Insulin Pancreatic islets TCF7L2 Type 2 diabetes AbbreviationsGLP1Glucagon-like peptide 1

GWASGenome-wide association study

SNPSingle-nucleotide polymorphism

TCF7L2Transcription factor 7-like 2

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Author: E. Renström

Source: https://link.springer.com/







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