Efficacy and safety of imidacloprid 10 %-moxidectin 1 % spot-on formulation in the treatment of feline infection by Capillaria aerophilaReport as inadecuate




Efficacy and safety of imidacloprid 10 %-moxidectin 1 % spot-on formulation in the treatment of feline infection by Capillaria aerophila - Download this document for free, or read online. Document in PDF available to download.

Parasitology Research

, Volume 111, Issue 4, pp 1793–1798

First Online: 11 July 2012Received: 01 June 2012Accepted: 21 June 2012

Abstract

The nematode Capillaria aerophila Trichuroidea, Trichuridae affects the respiratory system of cats and other animals and occasionally of human beings. Infected cats may show bronchovesicular sounds, inflammation, sneezing, wheezing and, chronic cough and, sometimes, bronchopneumonia and respiratory failure. The present study evaluated the efficacy and safety of the antiparasitic spot-on formulation containing imidacloprid 10 %-moxidectin 1 % Advocate®, Bayer Animal Health in the treatment of natural feline infection with the lungworm C. aerophila. The efficacy of Advocate® administered once was tested on days 7 ± 1 and 11 ± 1 following treatment at day 0 and compared to faecal egg counts on days −6 ± 1 and −2 ± 1. Overall, 36 cats treated either with Advocate® treatment group, n = 17 cats or left untreated control group, n = 19 cats were included in the study. Geometric means of faecal egg counts values in eggs per gram of faeces were 124.03 prior to treatment and 0.26 posttreatment in treatment group, while 107.03 and 123.94 pre- and posttreatment in the untreated cats. Post-baseline egg counts showed a 99.79 % reduction in Advocate®-treated animals in comparison with cats which were left untreated. Also, treated cats showed no adverse events. This trial demonstrated that Advocate® spot-on formulation is safe and effective in the treatment of feline lung capillariosis caused by C. aerophila.

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Author: Donato Traversa - Angela Di Cesare - Emanuela Di Giulio - Giuseppe Castagna - Roland Schaper - Gabriele Braun - Beate Loh

Source: https://link.springer.com/







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