Two-year follow-up of an open-label multicenter study of polyacrylamide hydrogel Bulkamid® for female stress and stress-predominant mixed incontinenceReport as inadecuate




Two-year follow-up of an open-label multicenter study of polyacrylamide hydrogel Bulkamid® for female stress and stress-predominant mixed incontinence - Download this document for free, or read online. Document in PDF available to download.

International Urogynecology Journal

, Volume 23, Issue 10, pp 1373–1378

First Online: 25 April 2012Received: 25 November 2011Accepted: 18 March 2012

Abstract

Introduction and hypothesisPolyacrylamide hydrogel PAHG, Bulkamid® is a promising urethral bulking agent. This article presents the 2-year follow-up results of a multicenter study of PAHG injections for treating stress and stress-predominant mixed urinary incontinence.

MethodsSubmucosal injection of PAHG was performed in 135 women with urinary incontinence, with subjective and objective assessment of the efficacy and safety 24 months postinjection.

ResultsAt 24 months, the subjective responder rate was 64 % a statistically non-significant reduction from 67 % at 12 months. The decreased number of incontinence episodes and urine leakage were maintained compared with the result from the 12-month evaluations, as were objective result rates and quality of life data. No safety issues occurred.

ConclusionsPAHG is an effective and safe treatment option for women with stress-predominant mixed urinary incontinence, with maintained medium-term responder rates.

KeywordsBulking Mixed incontinence Stress Polyacrylamide hydrogel Bulkamid  Download fulltext PDF



Author: Philip Toozs-Hobson - Waleed Al-Singary - Michelle Fynes - Gunilla Tegerstedt - Gunnar Lose

Source: https://link.springer.com/







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