The chemical constituents from the roots of Gentiana crassicaulis and their inhibitory effects on inflammatory mediators NO and TNF-αReport as inadecuate




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Natural Products and Bioprospecting

, Volume 2, Issue 5, pp 217–221

First Online: 18 September 2012Received: 08 August 2012Accepted: 03 September 2012

Abstract

Chemical study on the roots of Gentiana crassicaulis Duthie ex Burk Gentianaceae afforded 15 compounds, including two new iridoid glycosides, qinjiaosides B 1 and C 2 . Their structures were elucidated by spectroscopic methods and chemical evidence. The isolated iridoid glycosides 1, 4–6 and 8–11 were tested for their anti-inflammatory activity by the inhibitory effects on LPS-induced NO and TNF-α production in macrophage RAW264.7 cells. All of them showed inhibitory effects on inflammatory mediators NO at a concentration of 15 µM, while 5 and 9 displayed the most potential inhibitory effects on TNF-α with IC50 of 0.06 and 0.05 µM, respectively. The structure-activity relationships SARs of these iridoid derivatives were discussed.

Graphical abstractOpen image in new windowKeywordsGentiana crassicaulis Gentianaceae iridoid glycosides qinjiaosides This article is published with open access at Springerlink.com

Electronic Supplementary MaterialSupplementary material is available for this article at 10.1007-s13659-012-0067-3 and is accessible for authorized users.

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Author: Tao Lv - Min Xu - Dong Wang - Hong-Tao Zhu - Chong-Ren Yang - Tian-Tai Zhang - Ying-Jun Zhang

Source: https://link.springer.com/







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