A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticariaReport as inadecuate




A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria - Download this document for free, or read online. Document in PDF available to download.

Clinical and Translational Allergy

, 2:19

First Online: 01 October 2012Received: 16 July 2012Accepted: 20 August 2012

Abstract

The electronic records of 398 patients with chronic spontaneous urticaria CSU who had had a serum basophil histamine release assay BHRA performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients 26.4%. Fifty eight were treated with ciclosporin because they were H1 anti-histamine unresponsive. CSU patients with a positive BHRA were more likely to respond clinically P<0.001 and to have raised thyroid autoantibodies P<0.02 than those with a negative BHRA. The BHRA offers a useful predictive biomarker for a good response of H1 antihistamine-unresponsive CSU patients to ciclosporin.

KeywordsCiclosporin Chronic urticaria Basophil histamine release assay  Download fulltext PDF



Author: Kamran Iqbal - Kapil Bhargava - Per Stahl Skov - Sidsel Falkencrone - Clive EH Grattan

Source: https://link.springer.com/







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