The mammalian gene function resource: the international knockout mouse consortiumReport as inadecuate

The mammalian gene function resource: the international knockout mouse consortium - Download this document for free, or read online. Document in PDF available to download.

Mammalian Genome

, Volume 23, Issue 9–10, pp 580–586

First Online: 12 September 2012Received: 06 April 2012Accepted: 20 July 2012


In 2007, the International Knockout Mouse Consortium IKMC made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem ES cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Download fulltext PDF

Author: Allan Bradley - Konstantinos Anastassiadis - Abdelkader Ayadi - James F. Battey - Cindy Bell - Marie-Christine Birling - Jo


Related documents