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Mammalian Genome

, Volume 23, Issue 9–10, pp 580–586

First Online: 12 September 2012Received: 06 April 2012Accepted: 20 July 2012

Abstract

In 2007, the International Knockout Mouse Consortium IKMC made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem ES cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal www.knockoutmouse.org has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

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Author: Allan Bradley - Konstantinos Anastassiadis - Abdelkader Ayadi - James F. Battey - Cindy Bell - Marie-Christine Birling - Jo

Source: https://link.springer.com/







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