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Cilia

, 1:19

First Online: 01 October 2012Received: 27 April 2012Accepted: 29 June 2012

Abstract

Primary cilia are present on almost all vertebrate cells, and they have diverse functions in distinct tissues. Cilia are important for sensation in multiple capacities in contexts as different as the retina, kidney, and inner ear. In addition to these roles, cilia play a critical part in various developmental processes. Of particular importance is the development of the neural tube, where cilia are essential for the transduction of the Sonic Hedgehog Shh signaling pathway that specifies neuronal cell fates. This relationship is well established and is the most recognizable function for cilia in the neural tube, but it may be part of a larger picture. Here, we discuss the links between cilia and Shh signaling, as well as suggesting additional roles for cilia, and mechanisms for their placement, in the neural tube.

KeywordsCilia neural tube development PCP signaling Shh signaling AbbreviationsA-Panterior-posterior

BBSBardet-Biedl syndrome

CEconvergent extension

CSFcerebral spinal fluid

D-Vdorsal-ventral

IFTintraflagellar transport

NTDneural tube defect

PCPplanar cell polarity

Ptch1Patched

ShSonic Hedgehog

SmoSmoothened

SuFuSuppressor of Fused.

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Author: Sarah N Bay - Tamara Caspary

Source: https://link.springer.com/







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