Two new tirucallane triterpenoids from Aphanamixis grandifoliaReport as inadecuate

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Natural Products and Bioprospecting

, Volume 2, Issue 5, pp 222–226

First Online: 08 November 2012Received: 18 July 2012Accepted: 30 August 2012


Two new tirucallane triterpenoids, 2 α-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid 1 and 23E-2 α-hydroxytirucalla-7,23,25-triene-3-one 2 , along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione 3 , were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS data, and compound 3 was further confirmed by X-ray crystal diffraction analysis. Antimicrobial activities and insecticidal activities of these three compounds were also evaluated. Compound 1 showed good antimicrobial activity against Staphylococcus aureus with the MIC value of 1.56 µg-mL, while compounds 1 and 2 showed insecticidal activity at 100 ppm, with the corrected mortality 79.1% and 60.6%, respectively.

Graphical abstractOpen image in new windowKeywordsAphanamixis grandifolia Meliaceae 2,3-seco-tirucallane triterpenoid bioassays This article is published with open access at

Electronic Supplementary MaterialSupplementary material is available for this article at 10.1007-s13659-012-0059-3 and is accessible for authorized users.

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Author: Xiao-Ying Wang - Gui-Hua Tang - Chun-Mao Yuan - Yu Zhang - Li Hou - Qing Zhao - Xiao-Jiang Hao - Hong-Ping He


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