Two new neolignans from Manglietia insignisReport as inadecuate

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Natural Products and Bioprospecting

, Volume 2, Issue 5, pp 227–230

First Online: 20 November 2012Received: 26 July 2012Accepted: 17 October 2012


Two new neolignans, manneoinsigins A 1 and B 2 , together with four known lignans, were isolated from the leaves and stems of Manglietia insignis. The new compounds were established on the basis of extensive spectroscopic analyses. All compounds except 2 were tested for their cytotoxic activity. Compound 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC50 value of 23.5 µM.

Graphical abstractOpen image in new windowKeywordsMagnoliaceae Manglietia insignis neolignan cytotoxic activity This article is published with open access at

Electronic Supplementary MaterialSupplementary material is available for this article at 10.1007-s13659-012-0063-7 and is accessible for authorized users.

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Author: Shan-Zhai Shang - Ju-Ming Yan - Hai-Bo Zhang - Yi-Ming Shi - Zhong-Hua Gao - Xue Du - Yan Li - Wei-Lie Xiao - Han-Dong Su


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