Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol. Report as inadecuate




Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol. - Download this document for free, or read online. Document in PDF available to download.

Antonio Eblen-Zajjur ;Investigación Clínica 2010, 51 1

Author: Alfredo Del Giaccio

Source: http://www.redalyc.org/articulo.oa?id=372937679008


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Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Del Giaccio, Alfredo; Eblen-Zajjur, Antonio Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol. Investigación Clínica, vol.
51, núm.
1, 2010, pp.
77-86 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937679008 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 51(1): 77 - 86, 2010 Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol. Alfredo Del Giaccio1 and Antonio Eblen-Zajjur2. Servicio de Medicina Interna, Hospital Universitario “Dr.
Angel Larralde”, Instituto Venezolano de los Seguros Sociales y 2Departamento de Ciencias Fisiológicas, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. 1 Key words: Mechanical nociception, pain propranolol, digoxin, amlodipine. modulation, atenolol, pindolol, Abstract.
Calcium channel blockers, b adrenergic receptor blockers and Na-K ATPase inhibitors are widely used drugs, mainly for cardiovascular diseases.
Their pharmacological targets are not restricted to the cardivascular tissue, nociceptive system structures also express similar targets, which strongly suggests a direct effect on pain sensation.
To evaluate the pain intensity changes in outpatient groups, who receive these drugs as a therapy, a cross-sectional sampled, randomized patient groups receiving the calcium channel blocker amlodipine for blood hypertension (n=45), b adrenergic receptor blockers (propranolol, atenolol or pindolol; n=40) for blood hypertension, or digoxin (n=40) for heart failure, were compared to an aparen...





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