Effectiveness of melatonin in tardive dyskinesia. Report as inadecuate

Effectiveness of melatonin in tardive dyskinesia. - Download this document for free, or read online. Document in PDF available to download.

Edgardo Carrizo ; Dexy Prieto de Rincón ; Ciro Alberto Rincón ; Triana Asián ; Shirley Medina-Leendertz ; Ernesto Bonilla ;Investigación Clínica 2011, 52 3

Author: Fernando Castro

Source: http://www.redalyc.org/articulo.oa?id=372937685006


Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Castro, Fernando; Carrizo, Edgardo; Prieto de Rincón, Dexy; Rincón, Ciro Alberto; Asián, Triana; Medina-Leendertz, Shirley; Bonilla, Ernesto Effectiveness of melatonin in tardive dyskinesia. Investigación Clínica, vol.
52, núm.
3, 2011, pp.
252-260 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937685006 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 52(3): 252 - 260, 2011 Effectiveness of melatonin in tardive dyskinesia. Fernando Castro1,2, Edgardo Carrizo3, Dexy Prieto de Rincón4, Ciro Alberto Rincón1, Triana Asián1, Shirley Medina-Leendertz4 and Ernesto Bonilla3,4 Hospital Psiquiátrico de Maracaibo. Instituto de Resocialización Psiquiátrica La Sierrita. 3Instituto de Investigaciones Clínicas “Dr.
Américo Negrette”, Facultad de Medicina, Universidad del Zulia. 4Centro de Investigaciones Biomédicas IVIC-ZULIA, Maracaibo, Venezuela. 1 2 Key words: Tardive dyskinesia, melatonin, abnormal involuntary movements. Abstract.
Tardive Dyskinesia (TD) is a movement disorder associated with the clinical administration of antipsychotics.
It is believed that TD is due, among other factors, to an increase in the oxidative damage produced by free radicals.
Antioxidants, like vitamin E, have been used in the treatment of TD but there is no evidence of their effectiveness.
Melatonin (MEL) is 6 to 10 times more effective, as an antioxidant, than vitamin E and it has been used with an apparent higher effectiveness in the treatment of TD, although the results have not been conclusive.
A randomized, double blind, placebo controlled design was used to determine the effecti...

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