Comparison of gene expression profiling between lung fibrotic and emphysematous tissues sampled from patients with combined pulmonary fibrosis and emphysemaReport as inadecuate




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Fibrogenesis and Tissue Repair

, 5:17

Pulmonary Disease

Abstract

BackgroundCombined pulmonary fibrosis and emphysema CPFE is characterized by both emphysema of the upper zone and diffuse parenchymal lung disease with fibrosis of the lower zone of the lung on chest computed tomography. The aim of this study was to investigate the mechanism of CPFE regarding gene expressions by comparing the results of microarray sequences between fibrotic and emphysematous lesions in the lungs of CPFE patients.

ResultsThe expression profiles of the fibrotic and emphysematous lesions were remarkably different in terms of function. Genes related to the immune system, structural constituents of the cytoskeleton, and cellular adhesion were overexpressed in fibrotic lesions, while genes associated with the cellular fraction, cell membrane structures, vascular growth and biology, second-messenger-mediated signaling, and lung development all processes that contribute to the destruction and repair of cells, vessels, and the lung were overexpressed in emphysematous lesions.

ConclusionsThe differences in gene expression were detected in fibrotic and emphysematous lesions in CPFE patients. We propose that the development of coexisting fibrotic and emphysematous lesions in CPFE is implemented by these different patterns of gene expressions.

KeywordsEmphysematous lesion Cellular fraction Fibrotic lesion Gene expression profiles Immune system Lung AbbreviationsCPFECombined pulmonary fibrosis and emphysema

ECMExtracellular matrix

H and EHematoxylin and eosin

IPFIdiopathic pulmonary fibrosis

SLRSignal log ratio.

Electronic supplementary materialThe online version of this article doi:10.1186-1755-1536-5-17 contains supplementary material, which is available to authorized users.

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Author: Masayuki Hanaoka - Michiko Ito - Yunden Droma - Atsuhito Ushiki - Yoshiaki Kitaguchi - Masanori Yasuo - Keishi Kubo

Source: https://link.springer.com/







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