Thermal sintering: a novel technique in the design of gastroretentive floating tablets of propranolol hcl and its evaluation. Report as inadecuate




Thermal sintering: a novel technique in the design of gastroretentive floating tablets of propranolol hcl and its evaluation. - Download this document for free, or read online. Document in PDF available to download.

Ambedkar Sunil Songa ; Sreenivasa Rao Nali ; Janaki Ram Battu ; Latha Kukati ; Venkata Ramana Murthy Kolapalli ;Investigación Clínica 2012, 53 3

Author: Venkata Srikanth Meka

Source: http://www.redalyc.org/articulo.oa?id=372937689002


Teaser



Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Srikanth Meka, Venkata; Sunil Songa, Ambedkar; Rao Nali, Sreenivasa; Ram Battu, Janaki; Kukati, Latha; Murthy Kolapalli, Venkata Ramana Thermal sintering: a novel technique in the design of gastroretentive floating tablets of propranolol HCl and its evaluation. Investigación Clínica, vol.
53, núm.
3, julio-septiembre, 2012, pp.
223-236 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937689002 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 53(3): 223 - 236, 2012 Thermal sintering: a novel technique in the design of gastroretentive floating tablets of propranolol HCl and its evaluation. Venkata Srikanth Meka1, Ambedkar Sunil Songa2, Sreenivasa Rao Nali2, Janaki Ram Battu2, Latha Kukati3 and Venkata Ramana Murthy Kolapalli2. School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia. A.U.College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India. 3G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India 1 2 Keywords: gastroretentive, thermal sintering, propranolol HCl, polyethylene oxide. Abstract.
The aim of the present investigation was to formulate thermally sintered floating tablets of propranolol HCl, and to study the effect of sintering conditions on drug release, as well as their in vitro buoyancy properties.
A hydrophilic polymer, polyethylene oxide, was selected as a sintered polymer to retard the drug release.
The formulations were prepared by a direct compression method and were evaluated by in vitro dissolution studies. The results showed that sintering temperature and time of exposure greatly inf...





Related documents