Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol hcl. Report as inadecuate




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Ambedkar Sunil Songa ; Sreenivasa Rao Nali ; Janaki Ram Battu ; Venkata Ramana Murthy Kolapalli ;Investigación Clínica 2012, 53 1

Author: Venkata Srikanth Meka

Source: http://www.redalyc.org/articulo.oa?id=372937687008


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Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Srikanth Meka, Venkata; Sunil Songa, Ambedkar; Rao Nali, Sreenivasa; Ram Battu, Janaki; Murthy Kolapalli, Venkata Ramana Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl. Investigación Clínica, vol.
53, núm.
1, enero-marzo, 2012, pp.
60-70 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937687008 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 53(1): 60 - 70, 2012 Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl. Venkata Srikanth Meka, Ambedkar Sunil Songa, Sreenivasa Rao Nali, Janaki Ram Battu and Venkata Ramana Murthy Kolapalli. University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India. Keywords: effervescent, floating system, propranolol HCl, polyethylene oxide, in vitro buoyancy. Abstract.
The purpose of this research was to develop and evaluate effervescent gastric floating tablets of propranolol HCl.
The oral delivery of antihypertensive propranolol HCl was facilitated by preparing an effervescent floating dosage form which could increase its absorption in the stomach by increasing the drug’s gastric residence time.
In the present work, effervescent floating tablets were prepared with a hydrophilic carrier such as polyethylene oxide (PEO WSR N 60K and PEO WSR 303) as a release retarding agent and sodium bicarbonate as a gas generating agent.
The prepared tablets were evaluated for all their physicochemical properties, in vitro buoyancy, drug release and rate order kinetics.
From the results, P9 was selected as an optimize...





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