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BMC Psychiatry

, 12:163

Mood disorders


BackgroundThe aim of the current study was to investigate the cognitive correlates of repetitive transcranial magnetic stimulation rTMS in 10 treatment-resistant depression patients.

MethodsPatients received forty 20-min sessions of fast-frequency 10 Hz rTMS of the left dorsolateral prefrontal cortex DLPFC over 20 days. Concept-shift ability accuracy and duration of performance was assessed daily with a Modified Concept-Shifting Task mCST in patients and in eight healthy volunteers. General cognitive functioning test Repeatable Battery for the Assessment of Neuropsychological Status; RBANS, Beck Depression Inventory BDI and Hamilton Depression Rating Scale HAM-D were applied before the first and after the last rTMS.

ResultsCompared to before rTMS on the first 10 days, the patients performed the mCST significantly more accurately after rTMS on the last 10 days p < .001, partial eta squared=.78 while the same comparison in healthy volunteers was not statistically significant p = .256, partial eta squared=.18. A significant improvement in immediate memory on RBANS and reduction in BDI and HAM-D scores were also observed after the last compared to before the first rTMS.

ConclusionThe rTMS is associated with an improvement in selective cognitive functions that is not explained by practice effects on tasks administered repeatedly.

Trial registrationName: -Repetitive Transcranial Magnetic Stimulation rTMS in the treatment of depression, assessed with HAM-D over a four week period.-


Registration number: ACTRN012605000145606

KeywordsRepetitive transcranial magnetic stimulation rTMS Treatment-resistant depression Modified concept-shifting task mCST Left dorsolateral prefrontal cortex DLPFC AbbreviationsBDIBeck depression inventory

DLPFCDorsolateral prefrontal cortex

ECTElectroconvulsive therapy

HAM-DHamilton depression rating scale- 21 items

mCSTModified concept shifting task

RBANSRepeatable battery for the assessment of neuropsychological status

rTMSRepetitive transcranial magnetic stimulation.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-244X-12-163 contains supplementary material, which is available to authorized users.

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Autor: Karina K Kedzior - Vikram Rajput - Greg Price - Joseph Lee - Mathew Martin-Iverson


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