CD20-positive NK-T-cell lymphoma with indolent clinical course: report of case and review of literatureReport as inadecuate

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Diagnostic Pathology

, 7:133

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AbstractCD20-positive T-cell lymphoma is extremely rare and only two cases of CD20-positive NK-T-cell lymphoma with aggressive clinical courses have been described in the literature. We present a case of unusual NK-T-cell lymphoma with CD20 expression in nasal cavity occurring in an elder female patient. The patient had presented with left nasal cavity nodule for 10 years. CT scan revealed a mass was located at the left anterior nasal cavity and was observed to extend into the ethmoid sinus. There was no regional lymph node involvement. Biopsy was performed and microscopical inspection revealed the lesion was composed of small- to middle-size atypical lymphoid cell, histiocytes, eosinophils, and neutrophils. The lymphoid cells were strongly immunoreactive to CD3, CD20, CD56, TIA-1 and granzyme-B. The Epstein-Barr virus genomes were also found in tumor cells by in situ hybridization. By genetic analysis, however, no clonal rearrangement of the T cell receptor-γ genes TCRG, or the immunoglobulin heavy chain IgH gene was found. A diagnosis of CD20-positive extranodal NK-T-cell lymphoma, nasal type was made. The patient refused chemotherapy, and had been only on regular follow-up for 6 months. There was no sign of enlargement of tumor and extra-nasal dissemination by whole body positron emission tomography-computed tomography PET-CT study. The accurate diagnosis of NK-T-cell lymphoma with CD20 expression is important, but the indolent behavior of the present case is more unusual. A long-term follow-up is suggested to be performed to inspect the progression for this tumor.

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KeywordsNK-T cell lymphoma Nasal type CD20 expression Differential diagnosis Prognosis AbbreviationsNKNatural killer

TCRT-cell receptor

EBVEpstein-Barr virus

EBERsEBV-encoded RNAs

IGHImmunoglobulin heavy chain.

Electronic supplementary materialThe online version of this article doi:10.1186-1746-1596-7-133 contains supplementary material, which is available to authorized users.

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Author: Qing-ping Jiang - Shao-yan Liu - Yue-xin Yang - Xue-xian Tan - Juan Peng - Zhong-tang Xiong - Zhi Li


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