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BMC Infectious Diseases

, 12:259

First Online: 15 October 2012Received: 13 April 2012Accepted: 02 October 2012


BackgroundDay care-associated infectious diseases are widely recognized as a public health problem but rarely studied. Insights into their dynamics and their association with the day care setting are important for effective decision making in management of infectious disease control. This paper describes the purpose, design and potential of our national multi-center, day care-based sentinel surveillance network for infectious diseases the KIzSS network. The aim of the KIzSS network is to acquire a long-term insight into the syndromic and microbiological aspects of day care-related infectious diseases and associated disease burden and to model these aspects with day care setting characteristics.

Methods-designThe KIzSS network applies a prospective cohort design, following day care centers rather than individual children or staff members over time. Data on infectious disease symptoms and related morbidity children and staff, medical consumption, absenteeism and circulating enteric pathogens children are collected on a daily, weekly or monthly basis. Every two years, a survey is performed to assess the characteristics of participating day care centers.

DiscussionThe KIzSS network offers a unique potential to study infectious disease dynamics in the day care setting over a sustained period of time. The created biodatabases will help us to assess day care-related disease burden of infectious diseases among attending children and staff and their relation with the day care setting. This will support the much needed development of evidence-based and pragmatic guidelines for infectious disease control in day care centers.

KeywordsDay care Infectious disease Public health Surveillance Study design AbbreviationsCVICentral Veterinary Institute laboratory

DCCDay Care Center

EAECEnteroaggregative E. Coli

EPECTypical and Atypical Enteropathogenic E. Coli

ESBLExtended Spectrum Béta-Lactamases

KIzSSKinderdagverblijven Infectieziekten Surveillance Systeem

RIVMDutch National Institute for Public Health and the Environment

STECShigatoxin Producing E. Coli

qPCRquantitative Real-time Multiplex Polymerase Chain Reaction.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-12-259 contains supplementary material, which is available to authorized users.

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Autor: Remko Enserink - Harold Noel - Ingrid HM Friesema - Carolien M de Jager - Anna MD Kooistra-Smid - Laetitia M Kortbeek -


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