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Nutrition and Metabolism

, 9:90

First Online: 15 October 2012Received: 30 August 2012Accepted: 05 October 2012

Abstract

Calorie restriction CR; ~60% of ad libitum, AL intake has been associated with substantial alterations in body composition and insulin sensitivity. Recently, several proteins that are secreted by nontraditional endocrine tissues, including skeletal muscle and other tissues, have been discovered to modulate energy metabolism, body composition, and insulin sensitivity. The aim of this study was to characterize the influence of CR by rats on plasma levels of six of these newly recognized metabolic hormones BDNF, FGF21, IL-1β, myonectin, myostatin, and irisin. Body composition of 9-month old male Fischer-344-Brown Norway rats AL and CR groups was determined by nuclear magnetic resonance. Blood sampled from the carotid artery of unanesthetized rats was used to measure concentrations of glucose and plasma proteins. As expected, CR versus AL rats had significantly altered body composition reduced percent fat mass, increased percent lean mass and significantly improved insulin sensitivity based on the homeostasis model assessment-estimated insulin resistance index. Also consistent with previous reports, CR compared to AL rats had significantly greater plasma levels of adiponectin and corticosterone. However, there were no significant diet-related differences in plasma levels of BDNF, FGF21, IL-1β, myonectin, myostatin, or irisin. In conclusion, these results indicate that alterations in plasma concentration of these six secreted proteins are not essential for the CR-related improvement in insulin sensitivity in rats.

KeywordsMyonectin Myostatin FGF21 Irisin Insulin resistance Dietary restriction Adiponectin FNDC5 Electronic supplementary materialThe online version of this article doi:10.1186-1743-7075-9-90 contains supplementary material, which is available to authorized users.

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Autor: Naveen Sharma - Carlos M Castorena - Gregory D Cartee

Fuente: https://link.springer.com/



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