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DARU Journal of Pharmaceutical Sciences

, 20:66

First Online: 24 October 2012Received: 17 June 2012Accepted: 20 October 2012


BackgroundThe genus Salvia, with nearly 900 species, is one of the largest members of Lamiaceae family. In the Flora of Iran, the genus Salvia is represented by 58 species of which 17 species are endemic. Salvia hypoleuca Benth., is one of these species growing wildly in northern and central parts of Iran. Salvia species are well known in folk medicine and widely used for therapeutic purposes. Literature review shows that there is no report on phytochemical investigation of the roots of S. hypoleuca.

ResultsThe separation and purification process were carried out using various chromatographic methods. Structural elucidation was on the basis of NMR and MS data, in comparison with those reported in the literature. The isolated compounds were identified as sitosteryl oleate 1, β-sitosterol 2, stigmasterol 3, manool 4, 7α-acetoxy royleanone 5, ursolic acid 6, oleanolic acid 7, 3-epicorosolic acid 8, 3-epimaslinic acid 9 and coleonolic acid 10.

ConclusionsIn the present study, three sterols, two diterpenes and five triterpenes were isolated from the ethyl acetate extract of the roots of S. hypoleuca. As the chemotaxonomic significance, some of the isolated compounds 1–7, 9 have not been previously reported from the species S. hypoleuca, while the triterpenes 8 and 10 are now documented from Salvia genus for the first time.

KeywordsSalvia hypoleuca Coleonolic acid 7α-acetoxyroyleanone 3-epimaslinic acid 3-epicorosolic acid Manool Electronic supplementary materialThe online version of this article doi:10.1186-2008-2231-20-66 contains supplementary material, which is available to authorized users.

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Autor: Soodabeh Saeidnia - Mitra Ghamarinia - Ahmad R Gohari - Alireza Shakeri

Fuente: https://link.springer.com/

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