A new asymmetric synthesis of 2,6-cis-disubstituted-4-methylenpiperidines. Total synthesis of -alkaloid 241D and -isosolenopsin AReportar como inadecuado




A new asymmetric synthesis of 2,6-cis-disubstituted-4-methylenpiperidines. Total synthesis of -alkaloid 241D and -isosolenopsin A - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 SEESIB - Synthèse et étude de systèmes à intêret biologique

Abstract : A highly diastereoselective synthesis of 2,6-cis-disubstituted-4-methylenepiperidines based on a Mannich type intramolecular cyclization of an allylsilane on an iminium ion is described. The synthetic potential of this methodology is demonstrated by the enantioselective synthesis of two natural piperidine alkaloids: +-alkaloid 241D and +-isosolenopsin A





Autor: J. Monfray - Y. Gelas-Mialhe - J.-C. Gramain - R. Remuson -

Fuente: https://hal.archives-ouvertes.fr/



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