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Fibrogenesis and Tissue Repair

, 5:19

Cardiovascular DiseaseCardiovascular Diseases

Abstract

Wound healing, cardiac fibrosis, and infarct scar development, while possessing distinct features, share a number of key functional similarities, including extracellular matrix synthesis and remodeling by fibroblasts and myofibroblasts. Understanding the underlying mechanisms that are common to these processes may suggest novel therapeutic approaches for pathologic situations such as fibrosis, or defective wound healing such as hypertrophic scarring or keloid formation. This manuscript will briefly review the major steps of wound healing, and will contrast this process with how cardiac infarct scar formation or interstitial fibrosis occurs. The feasibility of targeting common pro-fibrotic growth factor signaling pathways will be discussed. Finally, the potential exploitation of novel regulators of wound healing and fibrosis ski and scleraxis, will be examined.

KeywordsCardiac infarct scar Collagen Fibrosis Wound healing AbbreviationsbFGFBasic fibroblast growth factor

CTGFConnective tissue growth factor

ECMExtracellular matrix

FGFFibroblast growth factor

HIF-1αHypoxia-inducible factor 1α

IGF-1Insulin-like growth factor 1

PDGFPlatelet-derived growth factor

TGF-βTransforming growth factor β.

Electronic supplementary materialThe online version of this article doi:10.1186-1755-1536-5-19 contains supplementary material, which is available to authorized users.

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Autor: Michael P Czubryt

Fuente: https://link.springer.com/



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