Exposure to polychlorinated biphenyl PCB congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50Report as inadecuate




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Breast Cancer Research and Treatment

, Volume 136, Issue 1, pp 267–275

First Online: 28 September 2012Received: 24 July 2012Accepted: 12 September 2012

Abstract

Discrete windows of susceptibility to toxicants have been identified for the breast, including in utero, puberty, pregnancy, and postpartum. We tested the hypothesis that polychlorinated biphenyls PCBs measured during the early postpartum predict increased risk of maternal breast cancer diagnosed before age 50. We analyzed archived early postpartum serum samples collected from 1959 to 1967, an average of 17 years before diagnosis mean diagnosis age 43 years for 16 PCB congeners in a nested case–control study in the Child Health and Development Studies cohort N = 112 cases matched to controls on birth year. We used conditional logistic regression to adjust for lipids, race, year, lactation, and body mass. We observed strong breast cancer associations with three congeners. PCB 167 was associated with a lower risk odds ratio OR, 75th vs. 25th percentile = 0.2, 95 % confidence interval 95 % CI 0.1, 0.8 as was PCB 187 OR, 75th vs. 25th percentile = 0.4, 95 % CI 0.1, 1.1. In contrast, PCB 203 was associated with a sixfold increased risk OR, 75th vs. 25th percentile = 6.3, 95 % CI 1.9, 21.7. The net association of PCB exposure, estimated by a post-hoc score, was nearly a threefold increase in risk OR, 75th vs. 25th percentile = 2.8, 95 % CI 1.1, 7.1 among women with a higher proportion of PCB 203 in relation to the sum of PCBs 167 and 187. Postpartum PCB exposure likely also represents pregnancy exposure, and may predict increased risk for early breast cancer depending on the mixture that represents internal dose. It remains unclear whether individual differences in exposure, response to exposure, or both explain risk patterns observed.

KeywordsPCBs Polychlorinated biphenyls Breast cancer Pregnancy Postpartum Prospective Human AbbreviationsOROdds ratio

PCBsPolychlorinated biphenyls

95 % CI95 percent confidence interval

An erratum to this article is available at http:-dx.doi.org-10.1007-s10549-016-3955-0.

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Author: Barbara A. Cohn - Mary Beth Terry - Marj Plumb - Piera M. Cirillo

Source: https://link.springer.com/







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