On the Interaction between a Nanoparticulate System and the Human Body in Body Area NanonetworksReportar como inadecuado

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1 FUN - Self-organizing Future Ubiquitous Network Inria Lille - Nord Europe 2 COMLAB - Digital Signal Processing Multimedia & Optical Communications Laboratory Rome 3 DEIS - Dipartimento di Elettronica Informatica e Sistemistica Rende

Abstract : In this work, we investigate the interaction of a nanoparticulate system for nanomedicine applications with the biological environment, i.e., the human body. Following the molecular communication paradigm, we assess how our nanoparticulate system model is suitable for coexistence in a biological environment. Specifically, we assume the presence of the human immune system that can affect the optimal behavior of nanoparticles, aiming to locally deliver drug inside the human body. When a flow of nanoparticles is injected into the blood, the interference due to the immune system can provide a strong decrease of the nanoparticle concentration, by means of -humoral immunity-, the phagocytosis process, etc. As a consequence, the correct drug delivery will occur with a lower probability. Since the mechanism behind the biological immune system is very complicated, in this paper, we start from a simplistic nanoparticulate model, where the nanoparticles and the cells of the immune system are subject to the diffusion laws. Finally, we derive the end-to-end physical model of our nanoparticulate nanomedicine system with the presence of the human immune system cells. The error analysis is then investigated in terms of how these errors can affect the performance of the system, i.e., nanoparticle survival probability.

Keywords : nano networks human immune system fault probability drug delivery

Autor: Valeria Loscri - Anna Maria Vegni - Giancarlo Fortino -

Fuente: https://hal.archives-ouvertes.fr/


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