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BMC Infectious Diseases

, 12:S7

First Online: 12 November 2012


A significant improvement in the rate of eradication of Hepatitis C Virus Genotype 1 has been achieved with the addition of Boceprevir and Telaprevir to pegylated interferon and ribavirin. These two drugs are the heralds of a new wave of antivirals that will improve the efficacy of pegylated interferon or even will substitute this drug in interferon free combinations. The results of phase II studies in patients naïve to treatment seem to be very promising strongly supporting the possibility of a large success for a first line all oral antiviral combination in interferon naïve. However, data observed in interferon experienced patients are less exciting and probably more complex treatment regimens will be needed to treat this patients’ population.

List of abbreviations usedDAADirectly Acting Antivirals

HCVHepatitis C Virus

PIProtease Inhibitors

SVRSustained Virologic Response

PIProtease Inhibitor

NS5b PolINS5b polymerase inhibitor

NS5a PolIPolymerase Inhibitor

PRPegylated Interferon combined with Ribavirin


SVR 4HCVRNA below the level of detection with Roche TaqMan assay 4 weeks after treatment withdrawal

SVR 24HCVRNA below the level of detection with Roche TaqMan assay 24 weeks after treatment withdrawal.

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Autor: Massimo Puoti - Roberto Rossotti - Giovanna Travi - Maurizio Orso - Maria Cristina Moioli


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