Phylogeny and phylodinamic of Hepatitis C in ItalyReportar como inadecuado

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BMC Infectious Diseases

, 12:S5

First Online: 12 November 2012


Hepatitis C virus infection HCV is one of the most pressing health emergencies in the world with a global prevalence of about 170 million people chronically infected worldwide. In Europe, Italy has the highest HCV prevalence 3 - 4.4% with peaks of 12.6 - 26% in Southern regions and the major islands. In Italy HCV genotype 1b prevails, and genotype 4 is mainly found in the south of the country where the prevalence is particularly high in regions such as Calabria.

Phylogenetics analysis is a molecular tool widely used to study rapidly-evolving RNA viruses that establish chronic infections such as HCV. Searching the scientific literature, it was found that thirty-nine genetic studies on HCV genotypes have been carried out in Italy between 1997 to 2012 years. However, phylogenetic analysis was performed only in fourteen out of thirty-nine HCV studies 36% considered. Monitoring the genetic evolution of HCV is an essential step to control the local as well as global HCV epidemic and to develop efficient preventive and therapeutic strategies.

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Autor: Massimo Ciccozzi - Alessandra Lo Presti - Anna Rita Ciccaglione - Gianguglielmo Zehender - Marco Ciotti


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