Commenting on the effects of surface treated- and non-surface treated TiO2 in the Caco-2 cell modelReportar como inadecuado




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Particle and Fibre Toxicology

, 9:42

First Online: 12 November 2012Received: 05 September 2012Accepted: 05 November 2012

Abstract

In a recent work published in Particle and Fibre Toxicology by Fisichella and coworkers investigating surface-modified TiO2 nanoparticle exposure in a model human intestinal epithelium Caco-2, albeit degraded to mimic conditions in the gut and exposure to natural sunlight, purportedly resulted in no toxic effects. The authors Fisichella et al. claim to have confirmed the results of a 2010 report by Koeneman et al. However, the study by Koeneman and colleagues revealed significant effects of unmodified TiO2 nanoparticles. These contradicting data warrant further investigation into the possible effects of aluminum hydroxide, as these nanoparticles appear to have resulted in an abnormal apical surface in Caco-2 cells.

This is a comment on http:-www.particleandfibretoxicology.com-content-pdf-1743-8977-9-18.pdf.

KeywordsNanoparticles Titanium dioxide Microvilli Brush-border Caco-2 Transmission electron microscopy Scanning electron microscopy  Download fulltext PDF



Autor: James J Faust - Wen Zhang - Brian A Koeneman - Yongsheng Chen - David G Capco

Fuente: https://link.springer.com/



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