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BMC Infectious Diseases

, 12:S6

First Online: 12 November 2012 Summary

A major goal of modern medicine is the application of personalized therapies, consisting of decisions and practices tailored to the individual patient. Information about genetic variants, either mutant or polymorphic, represents the basis for the development of this clinical approach. Recently, several independent genome-wide association studies GWAS have identified two single nucleotide polymorphisms SNPs on the IL28B locus associated with HCV containment, spontaneous clearance, treatment response, and disease progression. In this minireview we will concisely discuss some critical genetic concepts that may have possible implications for clinical decisions in the treatment of HCV infection.

AbbreviationsGWASgenome-wide association studies

SNPsingle nucleotide polymorphism

IL28Binterleukin 28B

HCVHepatitis C virus

PEG-IFNpegylated interferon

SRVsustained viral response

Jak-STATJanus kinase - Signal Transducer and Activator of Transcription.

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Autor: Stefania Nucara - Benedetto Caroleo - Vincenzo Guadagnino - Nicola Perrotti - Francesco Trapasso


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