Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovaryReportar como inadecuado

Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Ovarian Research

, 5:37

First Online: 21 November 2012Received: 15 August 2012Accepted: 30 October 2012


Epithelial ovarian cancer EOC remains the most lethal of all the gynaecological malignancies with drug resistance and recurrence remaining the major therapeutic barrier in the management of the disease. Although several studies have been undertaken to understand the mechanisms responsible for chemoresistance and subsequent recurrence in EOC, the exact mechanisms associated with chemoresistance-recurrence continue to remain elusive. Recent studies have shown that the parallel characteristics commonly seen between embryonic stem cells ESCs and induced pluripotent stem cells iPSC are also shared by a relatively rare population of cells within tumors that display stem cell-like features. These cells, termed ‘cancer initiating cells’ or ‘cancer stem cells CSCs’ have been shown not only to display increased self renewal and pluripotent abilities as seen in ESCs and iPSCs, but are also highly tumorigenic in in vivo mouse models. Additionally, these CSCs have been implicated in tumor recurrence and chemoresistance, and when isolated have consistently shown to express the master pluripotency and embryonic stem cell regulating gene Oct4. This article reviews the involvement of Oct4 in cancer progression and chemoresistance, with emphasis on ovarian cancer. Overall, we highlight why ovarian cancer patients, who initially respond to conventional chemotherapy subsequently relapse with recurrent chemoresistant disease that is essentially incurable.

KeywordsOvarian carcinoma Cancer stem cell Metastasis Chemoresistance Recurrence Embryonic stem cells Induced pluripotent stem cells Electronic supplementary materialThe online version of this article doi:10.1186-1757-2215-5-37 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Autor: Chantel Samardzija - Michael Quinn - Jock K Findlay - Nuzhat Ahmed


Documentos relacionados