Complicated intra-abdominal infections in Europe: a comprehensive review of the CIAO studyReport as inadecuate

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World Journal of Emergency Surgery

, 7:36

WSES guidelines, position papers and study group articles: 2010 to 2014


The CIAO Study -C omplicated Intra-A bdominal infection O bservational- Study is a multicenter investigation performed in 68 medical institutions throughout Europe over the course of a 6-month observational period January-June 2012.

Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections IAIs were included in the study.

2,152 patients with a mean age of 53.8 years range: 4–98 years were enrolled in the study. 46.3% of the patients were women and 53.7% were men. Intraperitoneal specimens were collected from 62.2% of the enrolled patients, and from these samples, a variety of microorganisms were collectively identified.

The overall mortality rate was 7.5% 163-2.152.

According to multivariate analysis of the compiled data, several criteria were found to be independent variables predictive of patient mortality, including patient age, the presence of an intestinal non-appendicular source of infection colonic non-diverticular perforation, complicated diverticulitis, small bowel perforation, a delayed initial intervention a delay exceeding 24 hours, sepsis and septic shock in the immediate post-operative period, and ICU admission.

Given the sweeping geographical distribution of the participating medical centers, the CIAO Study gives an accurate description of the epidemiological, clinical, microbiological, and treatment profiles of complicated intra-abdominal infections IAIs throughout Europe.

Electronic supplementary materialThe online version of this article doi:10.1186-1749-7922-7-36 contains supplementary material, which is available to authorized users.

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Author: Massimo Sartelli - Fausto Catena - Luca Ansaloni - Ari Leppaniemi - Korhan Taviloglu - Harry van Goor - Pierluigi Viale - D


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