Clinical relevance of novel Otarine herpesvirus-3 in California sea lions Zalophus californianus: lymphoma, esophageal ulcers, and strandingsReportar como inadecuado




Clinical relevance of novel Otarine herpesvirus-3 in California sea lions Zalophus californianus: lymphoma, esophageal ulcers, and strandings - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Veterinary Research

, 43:85

First Online: 12 December 2012Received: 08 August 2012Accepted: 26 November 2012

Abstract

Herpesviruses have been recognized in marine mammals, but their clinical relevance is not always easy to assess. A novel otarine herpesvirus-3 OtHV3 was detected in a geriatric California sea lion Zalophus californianus, and using a newly developed quantitative PCR assay paired with histology, OtHV3 was associated with esophageal ulcers and B cell lymphoblastic lymphoma in this animal. The prevalence and quantities of OtHV3 were then determined among buffy coats from 87 stranded and managed collection sea lions. Stranded sea lions had a higher prevalence of OtHV3 compared to managed collection sea lions 34.9% versus 12.5%; p = 0.04, and among the stranded sea lions, yearlings were most likely to be positive. Future epidemiological studies comparing the presence and viral loads of OtHV3 among a larger population of California sea lions with and without lymphoid neoplasia or esophageal ulcers would help elucidate the relevance of OtHV3-associated pathologies to these groups.

AbbreviationsHVHerpesvirus

HHVHuman herpesvirus

MLMaximum likelihood

MMPNavy Marine Mammal Program

NEMNegative stain electron microscopy

OtHVOtarine herpesvirus

PCRPolymerase chain reaction

qPCRQuantitative polymerase chain reaction

TEMTransmission electron microscopy

TMMCThe Marine Mammal Center

WAGWhelan and Goldman.

Electronic supplementary materialThe online version of this article doi:10.1186-1297-9716-43-85 contains supplementary material, which is available to authorized users.

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Autor: Stephanie Venn-Watson - Celeste Benham - Frances M Gulland - Cynthia R Smith - Judy St Leger - Pam Yochem - Hendrik Nolle

Fuente: https://link.springer.com/







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