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BMC Complementary and Alternative Medicine

, 12:252

Basic research


BackgroundEstrogen has been reported to accelerate cutaneous wound healing. This research studies the effect of young coconut juice YCJ, presumably containing estrogen-like substances, on cutaneous wound healing in ovairectomized rats.

MethodsFour groups of female rats 6 in each group were included in this study. These included sham-operated, ovariectomized ovx, ovx receiving estradiol benzoate EB injections intraperitoneally, and ovx receiving YCJ orally. Two equidistant 1-cm full-thickness skin incisional wounds were made two weeks after ovariectomy. The rats were sacrificed at the end of the third and the fourth week of the study, and their serum estradiol E2 level was measured by chemiluminescent immunoassay. The skin was excised and examined in histological sections stained with HandE, and immunostained using anti-estrogen receptor ER-α an ER-β antibodies.

ResultsWound healing was accelerated in ovx rats receiving YCJ, as compared to controls. This was associated with significantly higher density of immunostaining for ER-α an ER-β in keratinocytes, fibroblasts, white blood cells, fat cells, sebaceous gland, skeletal muscles, and hair shafts and follicles. This was also associated with thicker epidermis and dermis, but with thinner hypodermis. In addition, the number and size of immunoreactive hair follicles for both ER-α and ER-β were the highest in the ovx+YCJ group, as compared to the ovx+EB group.

ConclusionsThis study demonstrates that YCJ has estrogen-like characteristics, which in turn seem to have beneficial effects on cutaneous wound healing.

KeywordsYoung coconut juice Wound healing Estrogen ER-α ER-β Ovariectomy Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-12-252 contains supplementary material, which is available to authorized users.

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Autor: Nisaudah Radenahmad - Farid Saleh - Ibrahim Sayoh - Kitja Sawangjaroen - Patchara Subhadhirasakul - Piyakorn Boonyoung - Wil


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