Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral loadReportar como inadecuado




Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Infectious Diseases

, 12:374

Viral diseases

Abstract

BackgroundThe Interleukin 28B IL28B rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 HTLV-1 proviral load PvL and the development of the HTLV-1-associated myelopathy-tropical spastic paraparesis HAM-TSP.

MethodsIn an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects 81 HTLV-1 asymptomatic carriers, 24 individuals with HAM-TSP and 7 with Adult T cell Leukemia-Lymphoma ATLL.

ResultsAll 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes TT-CT were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM-TSP.

ConclusionsOur study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM-TSP in the Brazilian population.

KeywordsHTLV-1 ILB 28 polymorphisms HAM-TSP Proviral load Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-12-374 contains supplementary material, which is available to authorized users.

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Autor: Sabri Saeed Sanabani - Youko Nukui - Juliana Pereira - Antonio Charlys da Costa - Ana Carolina Soares de Oliveira - Rodri

Fuente: https://link.springer.com/



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