Hypertension and the development of New onset chronic kidney disease over a 10 year period: a retrospective cohort study in a primary care setting in MalaysiaReportar como inadecuado




Hypertension and the development of New onset chronic kidney disease over a 10 year period: a retrospective cohort study in a primary care setting in Malaysia - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Nephrology

, 13:173

First Online: 24 December 2012Received: 01 August 2012Accepted: 19 December 2012

Abstract

BackgroundLittle is known about the rate of progression to chronic kidney disease CKD among hypertensive patients, particularly at the primary care level. This study aims to examine risk factors associated with new onset CKD among hypertensive patients attending a primary care clinic.

MethodsThis is a 10-year retrospective cohort study of 460 patients with hypertension who were on treatment. Patient information was collected from patient records. CKD was defined as a glomerular filtration rate <60 ml-min per 1.73 m Cockcroft-Gault equation. Multiple logistic regression statistics was used to test the association in newly diagnosed CKD.

ResultsThe incidence of new CKD was 30.9% n = 142 with an annual rate of 3%. In multivariate logistic regression analysis, factors associated with development of new onset of CKD among hypertensive patients were older age odds ratio OR 1.123, 95% confidence interval CI 1.078-1.169, presence of diabetes OR 2.621, 95% CI 1.490-4.608, lower baseline eGFR OR 1.041, 95% CI 0.943-0.979 and baseline hyperuricaemia OR 1.004, 95% CI 1.001-1.007.

ConclusionsThe progression to new onset CKD is high among urban multiethnic hypertensive patients in a primary care population. Hence every effort is needed to detect the presence of new onset CKD earlier. Hypertensive patients who are older, with underlying diabetes, hyperuricaemia and lower baseline eGFR are associated with the development of CKD in this population.

KeywordsHypertension Chronic kidney disease Primary care Estimated glomerular filtration rate Cohort, Malaysia  Download fulltext PDF



Autor: Yook Chin Chia - Siew Mooi Ching

Fuente: https://link.springer.com/







Documentos relacionados