Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic-dengue shock syndrome - A prospective cohort studyReportar como inadecuado




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BMC Infectious Diseases

, 11:212

First Online: 05 August 2011Received: 13 April 2011Accepted: 05 August 2011

Abstract

BackgroundWorldwide there is a need to develop simple effective predictors that can distinguish whether a patient will progress from dengue fever DF to life threatening dengue hemorrhagic DHF or dengue shock syndrome DSS. We explored whether proteinuria could be used as such a marker.

MethodsWe included patients admitted to hospital with suspected dengue fever. Starting at enrollment until discharge, each patient-s daily spot urine protein creatinine ratio UPCR was measured. We classified those with confirmed dengue infection as DF or DHF including DSS based on WHO criteria. Peak and day of onset of proteinuria was compared between both groups.

ResultsCompared to those with DF, patients with DHF had significantly higher median peak proteinuria levels 0.56 versus 0.08 g-day; p < 0.001. For patients with DHF, the median day of onset of proteinuria was at 6 days of defervescence, with a range of -2 to +3 days after defervescence. There were three patients with DF who did not have proteinuria during their illness; the five remaining patients with DF had a median day of onset of proteinuria of was at 6 days of defervescence with a range of 0 to +28 days.

ConclusionsPeak UPCR could potentially predict DHF in patients with dengue requiring close monitoring and treatment.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-11-212 contains supplementary material, which is available to authorized users.

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Autor: Farhad F Vasanwala - Rukshini Puvanendran - Stephanie Fook-Chong - Joo-Ming Ng - Sufi M Suhail - Kheng-Hock Lee

Fuente: https://link.springer.com/







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