Reduced viscosity Barley β-Glucan versus placebo: a randomized controlled trial of the effects on insulin sensitivity for individuals at risk for diabetes mellitusReportar como inadecuado

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Nutrition and Metabolism

, 8:58

First Online: 16 August 2011Received: 07 June 2011Accepted: 16 August 2011


BackgroundPrior studies suggest soluble fibers may favorably affect glucose-insulin metabolism.

MethodsThis prospective, randomized, placebo controlled, double blind, parallel group trial evaluated 50 generally healthy subjects without prior diagnosis of diabetes mellitus 44 completers, who were administered beverages containing placebo control, lower dose 3 g-d, or higher dose 6 g-d reduced viscosity barley β-glucan BBG extract. Subjects 68% women mean age 56 years, Body Mass Index BMI 32 kg-m and baseline fasting plasma glucose 102 mg-dl were instructed to follow a weight-maintaining Therapeutic Lifestyle Changes TLC diet and consumed three 11 oz study beverages daily with meals for 12 weeks. The four primary study endpoint measures were plasma glucose and insulin each fasting and post-Oral Glucose Tolerance Testing OGTT.

ResultsCompared to placebo, administration of 3 g-d BBG over 12 weeks significantly reduced glucose incremental Area Under the Curve iAUC measures during OGTT and 6 g-d BBG over 12 weeks significantly reduced fasting insulin as well as the related homeostasis model assessment of insulin resistance HOMA-IR. Beverages were generally well tolerated with no serious adverse experiences and no significant differences between groups for adverse experiences. Per protocol instruction, subjects maintained body weight.

ConclusionsThese findings suggest 6 g-d BBG consumed in a beverage over 12 weeks may improve insulin sensitivity among hyperglycemic individuals with no prior diagnosis of diabetes mellitus, and who experience no change in body weight.

Trial Identifier:

Keywordsinsulin sensitivity insulinemia glycemia barley beta glucan randomized controlled trial List of abbreviationsAEAdverse Event

ANOVAAnalysis of Variance

BBGBarley β-Glucan

BMIBody Mass Index

BPBlood Pressure

bpmBeats Per Minute



GRASGenerally Regarded as Safe


HbA1cHemoglobin A1c

HOMA-IRhomeostasis model assessment of insulin resistance


HRHeart Rate

iAUCincremental Area Under the Curve


mMeter, mg: Milligram


OGTTOral Glucose Tolerance Test

SAESerious Adverse Event

SEMStandard Error of the Mean

TLCTherapeutic Lifestyle Changes

T2DMType 2 Diabetes Mellitus


Electronic supplementary materialThe online version of this article doi:10.1186-1743-7075-8-58 contains supplementary material, which is available to authorized users.

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Autor: Harold Bays - Joy L Frestedt - Margie Bell - Carolyn Williams - Lore Kolberg - Wade Schmelzer - James W Anderson


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