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Behavioral and Brain Functions

, 7:35

First Online: 16 August 2011Received: 27 April 2011Accepted: 16 August 2011


BackgroundSeveral lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta IL-1β in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms.

MethodsA total of 533 patients with schizophrenia 302 males: mean age ± standard deviation 43.4 ± 13.0 years; 233 females; mean age 44.8 ± 15.3 years and 1136 healthy controls 388 males: mean age 44.6 ± 17.3 years; 748 females; 46.3 ± 15.6 years were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1β gene rs2853550, rs1143634, rs1143633, rs1143630, rs16944 were examined for association with schizophrenia.

ResultsSignificant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 P = 0.0089. When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females P = 0.0073. A trend towards association was also found between rs16944 and female patients with schizophrenia P = 0.032.

ConclusionsThe present study shows the first evidence that the IL-1β gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1β gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1β in the etiology of schizophrenia.

Electronic supplementary materialThe online version of this article doi:10.1186-1744-9081-7-35 contains supplementary material, which is available to authorized users.

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Autor: Daimei Sasayama - Hiroaki Hori - Toshiya Teraishi - Kotaro Hattori - Miho Ota - Yoshimi Iijima - Masahiko Tatsumi - Teruhik

Fuente: https://link.springer.com/

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