Room temperature ionic liquids RTIL’s are convenient solvents for peptide synthesis!Reportar como inadecuado




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* Corresponding author 1 AHHBO - Asymétrie, hétérocycles, hétérochimie et bio-organique 2 Sciences et Méthodes Séparatives

Abstract : Dedicated to Professor Armand Lattes on his 50 th years teaching and research Abstract The chemical peptide coupling with modern coupling agents is efficient in ionic liquids. The reaction rate is fast enough, and the method offers some interests in the case of hindered amino acids, which are not easy to couple under standard conditions. Highly pure crude peptides are obtained in most cases compared to the corresponding coupling in classical solvents. Di-, tetra-, octa-and cyclo-peptides are conveniently synthesized in good yields, and various cheap coupling agents may be used.

Keywords : peptide synthesis amino acids coupling reagents Ionic liquids





Autor: Hélène Vallette - Laurent Ferron - Gérard Coquerel - Frédéric Guillen - Jean-Christophe Plaquevent -

Fuente: https://hal.archives-ouvertes.fr/



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