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Italian Journal of Pediatrics

, 37:38

Endocrinology

Abstract

An epidemic of pediatric obesity has occurred across the world in recent years. There are subgroups within the population at high-risk of becoming obese and especially of having experience of precocious cardiovascular and metabolic co-morbidities of obesity. One of these subgroups comprises patients treated for childhood cancers and namely survivors of craniopharyngioma. The high incidence of obesity in this group makes these patients an important disease model to better understand the metabolic disturbances and the mechanisms of weight gain among cancer survivors. The hypothalamic-pituitary axis damage secondary to cancer therapies or to primary tumor location affect long-term outcomes. Nevertheless, the aetiology of obesity in craniopharyngioma is not yet fully understood. The present review has the aim of summarizing the published data and examining the most accepted mechanisms and main predisposing factors related to weight gain in this particular population.

KeywordsObesity Craniopharyngioma Children Hypothalamic-pituitary axis AbbreviationsAGRPAgouti-Related Protein

ARCArcuate Nucleus

BMIBody Mass Index

CCSSChildhood Cancer Survivor Study

CSNCentral Nervous System

CVDCardiovascular Disease

FSIGTFrequently Sampled Intravenous Glucose Tolerance Test

GHGrowth Hormone

GHDGrowth Hormone Deficiency

GyGray

GLP-1Glucagon-Like Peptide 1

HOMAHomeostasis Model Insulin Resistance Index

IMTIntima Media Thickness

MSMetabolic Syndrome

NPYNeuropeptide Y

OGTTOral Glucose Tolerance Test

POMCPro-Opio-Melanocyte

RRRelative Risk

SDStandard deviation

SDSStandard Deviation Score

Α-MSHAlpha-Melanocyte Stimulating Hormone.

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Autor: Lorenzo Iughetti - Patrizia Bruzzi

Fuente: https://link.springer.com/



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