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Lipids in Health and Disease

, 10:176

First Online: 12 October 2011Received: 27 August 2011Accepted: 12 October 2011

Abstract

Obesity, a significant risk factor for various chronic diseases, is universally related to dyslipidemia mainly represented by decreasing high-density lipoprotein cholesterol HDL-C, which plays an indispensible role in development of cardiovascular disease CVD. However, the mechanisms underlying obesity and low HDL-C have not been fully elucidated. Previous studies have focused on the alteration of HDL catabolism in circulation following elevated triglyceride TG. But recent findings suggested that liver and fat tissue played pivotal role in obesity related low HDL-C. Some new molecular pathways like microRNA have also been proposed in the regulation of HDL metabolism in obesity. This article will review recent advances in understanding of the potential mechanism of low HDL-C in obesity.

KeywordsObesity HDL-C adipocytes hepatocytes microRNA-33 Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-10-176 contains supplementary material, which is available to authorized users.

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Autor: Hao Wang - Dao-Quan Peng

Fuente: https://link.springer.com/



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