GP96 is over-expressed in oral cavity cancer and is a poor prognostic indicator for patients receiving radiotherapyReportar como inadecuado

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Radiation Oncology

, 6:136

First Online: 12 October 2011Received: 28 April 2011Accepted: 12 October 2011


BackgroundOral cavity cancers ORC are the most common cancers, and standard treatment is radical surgery with postoperative radiotherapy. However, locoregional failure remains a major problem, indicating radioresistance an important issue. Our previous work has shown that GP96 contributed to radioresistance in nasopharyngeal and oral cancer cell lines. In this study, we determined clinical significance of GP96 in ORC by evaluation of GP96 expression and its association with disease prognosis in patients receiving radiotherapy

MethodsTotal of 79 ORC patients 77 males, median age: 48 years old receiving radical surgery and postoperative radiotherapy between Oct 1999 and Dec 2004 were enrolled. Patients in pathological stages II, III and IV were 16.5%, 16.5% and 67%, respectively. For each patient, a pair of carcinoma tissue and grossly adjacent normal mucosa was obtained. GP96-expression was examined by western blot analysis, and the association with clinicopathological status was determined.

ResultsThree-year locoregional control LRC, distant metastasis-free survival DMFS, disease-specific survival DSS and overall survival OS rates were 69%, 79%, 63% and 57%, respectively. We found that 55 patients 70% displayed GP96-overexpression in the tumor tissue, which correlated with a higher pN stage p = 0.020 and tumor depth > 10 mm p = 0.045. Nodal extracapsular spreading ECS and GP96-overexpression predicted adverse LRC p = 0.049 and p = 0.008. When stratified by nodal ECS, the adverse impact of GP96 remained significant in three-year LRC p = 0.004. In multivariate analysis, GP96-overexpression was also an independent predictor of LRC, DSS and OS p = 0.018, p = 0.011 and p = 0.012.

ConclusionGP96 may play roles in radioresistance which attributes to tumor invasiveness in oral cancer patients receiving radiotherapy. GP96 may serve as a novel prognostic marker of radiotherapy. However, further independent studies are required to validate our findings in a larger series.

KeywordsGP96 oral cavity cancers prognosis radioresistance List of abbreviationsORCOral cavity cancer

Postop-RTPostoperative radiotherapy

HspHeat shock protein

NPCNasopharyngeal carcinoma

CTComputed tomography

MRIMagnetic resonance image

IMRTIntensity-modulated radiotherapy

ECSExtracapuslar spreading

LRCLocoregional control

DSSDisease-specific survival

DMFSDistant metastasis-free survival

DFSdisease-free survival

OSOverall survival

EREndoplasmic reticulum

Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-6-136 contains supplementary material, which is available to authorized users.

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Autor: Chien-Yu Lin - Ting-Yang Lin - Hung-Ming Wang - Shiang-Fu Huang - Kang-Hsing Fan - Chun-Ta Liao - I-How Chen - Li-Yu Lee -


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