The impact of inflammation on bone mass in childrenReport as inadecuate

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Pediatric Nephrology

, Volume 26, Issue 11, pp 1937–1946

First Online: 01 January 2011Received: 13 November 2009Revised: 30 November 2010Accepted: 01 December 2010


Bone is a dynamic tissue. Skeletal bone integrity is maintained through bone modeling and remodeling. The mechanisms underlying this bone mass regulation are complex and interrelated. An imbalance in the regulation of bone remodeling through bone resorption and bone formation results in bone loss. Chronic inflammation influences bone mass regulation. Inflammation-related bone disorders share many common mechanisms of bone loss. These mechanisms are ultimately mediated through the uncoupling of bone remodeling. Cachexia, physical inactivity, pro-inflammatory cytokines, as well as iatrogenic factors related to effects of immunosuppression are some of the common mechanisms. Recently, cytokine signaling through the central nervous system has been investigated for its potential role in bone mass dysregulation in inflammatory conditions. Growing research on the molecular mechanisms involved in inflammation-induced bone loss may lead to more selective therapeutic targeting of these pathological signaling pathways.

KeywordsInflammation Bone mass regulation Osteodystrophy Chronic kidney disease End-stage renal disease  Download fulltext PDF

Author: Wai W. Cheung - Jian-Ying Zhan - Kyung Hoon Paik - Robert H. Mak


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