Epidemiology and cost of herpes zoster and postherpetic neuralgia among patients treated in primary care centres in the valencian community of SpainReportar como inadecuado




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BMC Infectious Diseases

, 11:302

Viral diseases

Abstract

BackgroundData on the epidemiology and costs related to herpes zoster HZ and postherpetic neuralgia PHN in Spain are scarce; therefore, studies are needed to evaluate the epidemiological and economic impact of HZ and its most common complication, PHN. The present study aimed to estimate the clinical and economic burden of HZ and PHN in Valencia Spain.

MethodsWe prospectively analyzed the burden of HZ and PHN and their attributable costs in patients from 25 general practices in the Autonomous Community of Valencia serving 36,030 persons aged > 14 years. All patients with a clinical diagnosis of HZ who attended these centers between December 1 2006 and November 30 2007 were asked to participate. Patients included were followed for 1 year.

ResultsOf the 130 cases of HZ followed up, continued pain was experienced by 47.6% 95% confidence interval CI = 35.6-56.7% at 1 month after rash onset, by 14.5% 95% CI = 7.8-1.2% at 3 months, by 9.0% 95% CI = 3.7-14.3% at 6 months, and by 5.9% 95% CI = 1.5-10.3% at 12 months. The percentage of patients with PHN increased with age, from 21.4% 95% CI = 8.3-40 in patients < 50 years to 59.2% 95% CI = 44.4-74 in patients ≥ 70 years. The estimated total cost for the 130 HZ cases during the follow-up period was €49,160 $67,349. Mean cost per patient was €378 range 53-2,830 $517, range 73-3,877.

ConclusionsThis study shows that PHN is a relatively common complication of HZ and that both conditions combined give rise to a significant clinical and economic burden for patients and providers.

AbbreviationsHZherpes zoster

VZVvaricella zoster virus

PHNpostherpetic neuralgia

CIconfidence interval

GPgeneral practitioner PHN1: PHN at 1 month

PHN3PHN at 3 months

PHN6PHN at 6 months

PHN12PHN at 12 months

€euros

$US dollars

ORodds ratio

SDstandard deviation

TPPThird-Party Payer

£GB pounds

GPNgross national product

AandEAccident and emergency departments.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-11-302 contains supplementary material, which is available to authorized users.

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Autor: Ana M Cebrián-Cuenca - Javier Díez-Domingo - María San-Martín-Rodríguez - Joan Puig-Barberá - Jorge Navarro-Pérez - t

Fuente: https://link.springer.com/







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